Clinician's Pocket Drug Reference 2016 by Leonard G. Gomella & Steven A. Haist & Aimee G. Adams

Author:Leonard G. Gomella & Steven A. Haist & Aimee G. Adams [Gomella, Leonard G.]
Language: eng
Format: azw3
Publisher: McGraw-Hill Education
Published: 2015-12-22T05:00:00+00:00

Nelfinavir (Viracept) Uses: *HIV Infxn, other agents* Acts: Protease inhib causes immature, noninfectious virion production Dose: Adults. 750 mg PO tid or 1250 mg PO bid. Peds. 25–35 mg/kg PO tid or 45–55 mg/kg bid; take w/ food W/P: [B, –] Many drug interactions; do not use w/salmeterol, colchicine (w/ renal/hepatic failure); adjust dose w/ bosentan, tadalafil for PAH; do not use tid dose w/PRG CI: Phenylketonuria, w/ triazolam/midazolam use or drug dependent on CYP3A4 (Table 10, p 356); w/ alpha 1-adrenoreceptor antag (alfuzosin), PDE5 inhib sildenafil Disp: Tabs 250, 625 mg; powder 50 mg/g SE: Food ↑ absorption; interacts w/ St. John’s wort; dyslipidemia, lipodystrophy, D, rash, ↑ QT interval Notes: PRG registry; tabs can be dissolved in water; monitor LFTs

Neomycin (Neo-Fradin, Generic) BOX: Systemic absorption of oral route may cause neuro-/oto-/nephrotox; resp paralysis possible w/ any route of administration Uses: *Hepatic coma, bowel prep* Acts: Aminoglycoside, poorly absorbed PO; ↓ GI bacterial flora Dose: Adults. 4–12 g/24 h PO in 3–4 ÷ doses; 12 g/d max; not > 2 wk Peds. 50–100 mg/kg/24 h PO in 3–4 ÷ doses W/P: [D, ?/–] Renal failure, neuromuscular disorders, hearing impair CI: Intestinal obst, GI inflam/ulcerative Dz Disp: Tabs 500 mg; PO soln 125 mg/5 mL SE: Hearing loss w/ long-term use; rash, N/V Notes: Do not use parenterally (↑ tox); part of the Condon bowel prep; also topical form

Neomycin/Bacitracin/Polymyxin B, Topical (Neosporin Ointment) (See Bacitracin/Neomycin/Polymyxin B, Topical [Neosporin Ointment], p 67); Neomycin/Colistin/Hydrocortisone (Cortisporin-TC Otic Drops); Neomycin/Colistin/Hydrocortisone/Thonzonium (Cortisporin-TC Otic Suspension) Uses: *Otitis externa*, Infxns of mastoid/fenestration cavities Acts: Abx w/ anti-inflam Dose: Adults. 5 gtt in ear(s) q6–8h Peds. 3–4 gtt in ear(s) q6–8h CI: Component allergy; HSV, vaccinia, varicella W/P: [B, ?] Disp: Otic gtt & susp SE: Local irritation, rash Notes: Shake well, limit use to 10 d to minimize ototox

Neomycin/Dexamethasone (AK-Neo-Dex Ophthalmic, NeoDecadron Ophthalmic) Uses: *Steroid-responsive inflam conditions of the cornea, conjunctiva, lid, & anterior segment* Acts: Abx w/ anti-inflam corticosteroid Dose: 1–2 gtt in eye(s) q3–4h or thin coat q6–8h until response, then ↓ to daily W/P: [C, ?] Disp: Cream: neomycin 0.5%/dexamethasone 0.1%; oint: neomycin 0.35%/dexamethasone 0.05%; soln: neomycin 0.35%/dexamethasone 0.1% SE: Local irritation Notes: Use under ophthalmologist’s supervision; no contacts w/ use

Neomycin/Polymyxin B (Neosporin Cream) [OTC] Uses: *Infxn in minor cuts, scrapes, & burns* Acts: Bactericidal Dose: Apply bid-qid W/P: [C, ?] CI: Component allergy Disp: Cream: neomycin 3.5 mg/polymyxin B 10,000 units/g SE: Local irritation Notes: Different from Neosporin oint

Neomycin/Polymyxin B Bladder Irrigant (Neosporin GU Irrigant) Uses: *Cont irrigant prevent bacteriuria & gram(–) bacteremia associated w/ indwelling catheter* Acts: Bactericidal; not for Serratia sp or streptococci Dose: 1 mL irrigant in 1 L of 0.9% NaCl; cont bladder irrigation w/ 1 L of soln/24 h 10 d max W/P: [D] CI: Component allergy Disp: Soln neomycin sulfate 40 mg & polymyxin B 200,000 units/mL; amp 1, 20 mL SE: Rash, neomycin ototox or nephrotox (rare) Notes: Potential for bacterial/fungal super-Infxn; not for Inj; use only 3-way catheter for irrigation

Neomycin/Polymyxin B/Hydrocortisone, (Cortisporin Ophthalmic, Generic) Uses:

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